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Kenneth A Jacobson Selected Research

Ligands

6/2022Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes.
4/2022Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer's Disease.
1/2021Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists.
12/2013Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches.
6/2013Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.
9/2012G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions.
1/2012Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.
6/2011GPCR ligand dendrimer (GLiDe) conjugates: adenosine receptor interactions of a series of multivalent xanthine antagonists.
10/2008Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.

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Kenneth A Jacobson Research Topics

Disease

29Neoplasms (Cancer)
10/2022 - 01/2005
24Inflammation (Inflammations)
03/2022 - 01/2002
21Ischemia
04/2022 - 03/2003
21Neuralgia (Stump Neuralgia)
01/2022 - 01/2012
20Pain (Aches)
04/2022 - 06/2003
20Astrocytoma (Pilocytic Astrocytoma)
01/2021 - 01/2002
11Hypoxia (Hypoxemia)
01/2022 - 06/2003
10Chronic Pain
07/2021 - 05/2012
9Asthma (Bronchial Asthma)
01/2022 - 11/2005
9Infarction (Infarctions)
01/2020 - 06/2005
9Heart Failure
01/2020 - 08/2005
8Parkinson Disease (Parkinson's Disease)
04/2022 - 05/2011
8Neurodegenerative Diseases (Neurodegenerative Disease)
04/2022 - 03/2009
7Thrombosis (Thrombus)
01/2019 - 04/2005
6Hypothermia
01/2022 - 02/2016
6Psoriasis (Pustulosis Palmaris et Plantaris)
01/2022 - 01/2009
5Obesity
01/2022 - 04/2020
5Dry Eye Syndromes (Dry Eye Syndrome)
01/2020 - 07/2010
5Cystic Fibrosis (Mucoviscidosis)
12/2016 - 05/2004
5Myocardial Infarction
05/2014 - 04/2006
5Reperfusion Injury
09/2012 - 01/2006
4Insulin Resistance
10/2021 - 01/2017
4Glaucoma
03/2021 - 01/2009
4Rheumatoid Arthritis
01/2019 - 01/2005
3Peripheral Nervous System Diseases (PNS Diseases)
01/2022 - 12/2014
3Type 2 Diabetes Mellitus (MODY)
01/2022 - 04/2013
3Hyperalgesia
01/2022 - 02/2015
3Hypersensitivity (Allergy)
01/2021 - 02/2015
3Body Weight (Weight, Body)
01/2021 - 02/2007
3Stroke (Strokes)
12/2020 - 05/2014
3Cardiovascular Diseases (Cardiovascular Disease)
10/2016 - 05/2010
3Leukemia
07/2013 - 03/2002
2Alzheimer Disease (Alzheimer's Disease)
04/2022 - 03/2009
2Pneumonia (Pneumonitis)
01/2022 - 05/2004
2Neuroinflammatory Diseases
01/2022 - 01/2020
2Cognitive Dysfunction
01/2022 - 01/2022
2Atrial Fibrillation
03/2021 - 05/2011
2Fibrosis (Cirrhosis)
01/2021 - 02/2014
2Hepatocellular Carcinoma (Hepatoma)
01/2021 - 01/2019
2Metabolic Diseases (Metabolic Disease)
01/2021 - 12/2020
2Non-alcoholic Fatty Liver Disease
01/2021 - 01/2020
2Colitis
01/2020 - 12/2017
2Abdominal Pain (Pain, Abdominal)
01/2020 - 12/2017

Drug/Important Bio-Agent (IBA)

44Purinergic P1 Receptors (Adenosine Receptor)IBA
06/2022 - 07/2002
37Adenosine (Adenocard)FDA LinkGeneric
01/2022 - 09/2003
15NucleotidesIBA
01/2022 - 06/2003
15Pharmaceutical PreparationsIBA
01/2022 - 05/2004
13Adenosine Triphosphate (ATP)IBA
03/2022 - 02/2003
10N(6)- (3- iodobenzyl)- 5'- N- methylcarboxamidoadenosineIBA
07/2021 - 03/2002
9LigandsIBA
06/2022 - 10/2008
9NucleosidesIBA
01/2022 - 09/2003
9Purinergic Receptors (Receptors, Purine)IBA
01/2022 - 02/2007
9Uridine Diphosphate (UDP)IBA
01/2021 - 06/2003
9Type C PhospholipasesIBA
05/2014 - 01/2002
8CalciumIBA
03/2021 - 02/2003
6UridineIBA
01/2022 - 04/2005
6MRS5698IBA
01/2021 - 12/2014
6Adenosine Diphosphate (ADP)IBA
02/2015 - 12/2002
6Uridine Triphosphate (UTP)IBA
05/2014 - 04/2005
5Adenosine A3 ReceptorIBA
03/2022 - 01/2015
5Adenosine Monophosphate (AMP)IBA
01/2022 - 06/2010
5Glucose (Dextrose)FDA LinkGeneric
01/2022 - 05/2010
5Adenosine A1 ReceptorIBA
10/2021 - 08/2015
5Adenosine KinaseIBA
04/2021 - 01/2015
5Uridine Diphosphate Glucose (UDP Glucose)IBA
01/2021 - 12/2009
5methylthio-ADPIBA
10/2007 - 07/2004
4Analgesics (Analgesic Drugs)IBA
01/2022 - 01/2015
4GTP-Binding Proteins (G-Protein)IBA
10/2019 - 05/2014
4Purinergic P1 Receptor AgonistsIBA
01/2019 - 12/2014
4purinoceptor P2Y6IBA
10/2017 - 06/2003
4CalsequestrinIBA
01/2015 - 02/2007
3Purinergic P1 Receptor AntagonistsIBA
04/2022 - 02/2014
3AdiponectinIBA
01/2022 - 01/2017
3Opioid Analgesics (Opioids)IBA
01/2022 - 01/2020
3ProdrugsIBA
01/2022 - 05/2014
3Proteins (Proteins, Gene)FDA Link
07/2021 - 07/2005
3Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
03/2021 - 11/2014
3Interleukin-10 (Interleukin 10)IBA
01/2021 - 02/2015
3Paclitaxel (Taxol)FDA LinkGeneric
01/2020 - 05/2012
3Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2020 - 05/2012
3Purinergic P2Y1 ReceptorsIBA
01/2020 - 07/2005
3Prasugrel HydrochlorideFDA Link
01/2019 - 07/2012
3TicagrelorIBA
01/2019 - 07/2012
3Clopidogrel (Plavix)FDA Link
01/2019 - 07/2012
34- (2- chloro- 6- (3- chlorobenzylamino)- 9H- purin- 9- yl)- 2,3- dihydroxy- N- methylbicyclo(3.1.0)hexane- 1- carboxamideIBA
09/2010 - 01/2006
3Phosphotransferases (Kinase)IBA
04/2009 - 06/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2006 - 06/2003
2Amyloid (Amyloid Fibrils)IBA
04/2022 - 01/2022
2Peptides (Polypeptides)IBA
04/2022 - 01/2022
2Caffeine (No Doz)FDA LinkGeneric
01/2022 - 11/2014
2GlucocorticoidsIBA
01/2021 - 12/2010
2Morphine (MS Contin)FDA LinkGeneric
01/2020 - 12/2017
2MRS 2339IBA
01/2020 - 02/2007
2bicyclo(3.1.0)hexaneIBA
01/2020 - 02/2013
2Phosphates (Orthophosphate)IBA
01/2020 - 02/2013

Therapy/Procedure

16Therapeutics
04/2022 - 01/2006
5Drug Therapy (Chemotherapy)
01/2022 - 12/2014
3Analgesia
01/2015 - 06/2003
3Ligation
06/2013 - 10/2006
2Immunotherapy
10/2022 - 01/2022